Efficacy of Tubulin Polymerization Inhibitor in Myelodysplastic Syndrome

cytotoxicity effects of new analogues of combretastatin as selective tubulin polymerization inhibitor in human carcinoma cell line

BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy.

Vascular disruption agents (VDA) cause occlusion of tumor vasculature, resulting in hypoxia-driven tumor cell necrosis. Tumor vascular disruption is a therapeutic strategy of great potential; however, VDAs currently under development display a narrow therapeutic margin, with cardiovascular toxicity posing a dose-limiting obstacle. Discovery of new VDAs, which display a wider therapeutic margin,...

5368 Tubulin Polymerization in Dimethyl Sulfoxide

The self-assembly of tubulin devoid of microtubuleassociated proteins (MAPs) has been studied using a MES buffer containing dimethyl sulfoxide (MezSO). Between 6% and 12% v/v MeZSO, the tubulin forms polymers which resemble microtubules in their morphology and chemical properties. These MezSO microtubules, like normal microtubules, require GTP for assembly and are sensitive to cold, calcium ion...

Heterogeneous Tau-Tubulin Complexes Accelerate Microtubule Polymerization.

Tau is an intrinsically disordered protein with a central role in the pathology of a number of neurodegenerative diseases. Tau normally functions to stabilize neuronal microtubules, although the mechanism underlying this function is not well understood. Of note is that the interaction between tau and soluble tubulin, which has implications both in understanding tau function as well as its role ...

Tubulin polymerization promoting protein 1 (TPPP1)

The eukaryotic cell cycle relies heavily on the mechanical forces vested by the dynamic rearrangement of the microtubule (MT) network. Tubulin Polymerization promoting Protein 1 (TPPP1) alters MT dynamics by driving MT polymerization as well as stabilization, via increasing MT acetylation. It increases MT rigidity, which results in reduced cell proliferation through downregulation of G1/S-phase...